![]() Also included are Random Task Force Operations, and completion of these give players a large bonus in addition to simply completing the challenge and reaping those rewards. These dungeon-style events are now all called Task Force Operations, to make them more uniform and grouped together. After that, players have access to the Task Force Operation version of the Defense, which is a group-based instanced battle. The second mission, “Downfall,” will culminate in the defense of Star Base One. Each faction has their own introduction to the mission (“Secrets”), but it all winds up on the same path: We’re heading to the Delta Volanis Science Station to lend them aid. That part made me pretty happy, because I genuinely enjoyed the mission, and went back through it on my Romulan character I was leveling in my downtime. If you take the Age of Discovery episodes as an established player, you’ll leap right into the heart of the action, without any of the content that occurs down in Starfleet Academy. These missions are both fun for seasoned players, such as myself, and newcomers to the game. But it was not always this way, and this war with the Klingons is a good example of that.īoth of these missions are a lot of fun, as you can see in our Let’s Plays for the MMOHuts Youtube channel included in this article, which you should absolutely watch. One of the major points of the Star Trek franchise is understanding, science, and exploration. This is a chaotic, war-torn time in the Star Trek universe, which makes it an excellent starting point for the fighting that goes on in STO. There’s only one recorded that I’m aware of. The Klingon side also suffered losses, and at least one ship was destroyed, though perhaps more than that. This is just after the Battle at the Binary Stars, where thousands of lives and at least seven starships were destroyed on the Federation side alone. This is the beginning of Star Trek, during the Klingon War. He’s spoken of at the academy, but he’s not the historic figure he will later become in the Star Trek universe. 2256: at this point in time, Kirk isn’t really all that important yet, hasn’t hit the rank of Captain. The Age of Discovery content is also interesting because of where and when in the Star Trek universe it takes place. Fortunately, these episodes are not lengthy, with the first being longer because it contains a tutorial. It is, however, the perfect starting point for a new player to jump into the game. All factions, all races can take part in these episodes without having to make a new character. This is really great for new players, as you start a new character, in a new storyline, and once you complete the first two stories, you’re in the thick of the regular game. Players can access this new content by making a new character in the “Discovery-era” Federation or by simply logging onto their regular character. That’s incredible, and something I certainly wanted as a kid. ![]() Sure, Star Trek: The Next Generation had Super Nintendo games when it was still airing, but this is an MMO with thousands upon thousands playing actively, able to play a story that is presently unfolding before our eyes. Perhaps the most interesting is that it is the first time Star Trek Online has had a storyline that was a part of an on-going and currently-running series. There are a lot of fascinating parts about the Age of Discovery update. I am a mediocre Starship captain at best, but I honestly have so much fun playing the episodes of Star Trek Online. I got into Star Trek Online terribly late, so there was a Hell of a lot to learn.
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![]() They're mostly too small-minded to plot a world takeover, but their craven intellectual vanity gives them plenty of license to kill. 58 mins The Hardest Challenge reveals the extraordinary range of techniques predators use to catch their prey - from a leopard using all its powers of stealth to stalk impala in broad daylight and wild dogs, whose tactic is to wear down their prey over long distances. It's impossible to get straight answers out of subjects like this, but that's an answer, too. This docuseries is really about the minds of two preternaturally clever psychopaths. In the Grip of the Seasons looks at the challenges of. When the police arrive at her door, she's got a dead body in her freezer and a wild tale to tell. The Hardest Challenge reveals the extraordinary range of techniques predators use to catch their prey - from a leopard using all its powers of stealth to stalk impala in broad daylight and wild dogs, whose tactic is to wear down their prey over long distances. She's got a string of degrees and an even longer trail of mysteriously dead exes. If William is the engineer, Marjorie is the master of hacking the human mind. It's Rothstein's sometimes-girlfriend Marjorie Diehl-Armstrong at the center of the series, though. He's a self-styled "fractured intellectual," a tinkerer with a devious mind and an anti-social personality reminiscent of The Unabomber, Ted Kaczynski. It turns out a man named William Rothstein constructed the device and the elaborate plot. Police say he was involved his family says he was the victim of a duo of "Evil Genius" former lovers at the center of this twisted tale. Sheela becomes insidiously institutionalized, at her own capable hands, and is willing to do anything to prop up the evil edifice she has built. ![]() It's more like she loves Osho maternally, but loves the power of the bureaucracy she's built around this man's spiritual grift even more. Indian Predator: The Butcher of Delhi is an Indian Netflix true crime docuseries which premiered on 20 July 2022. But Osho's chief of staff, Sheela, is the actual center of this doc. It's not surprising stuff if you know the true crime cult genre. And like so many false prophets, this supposedly transcendent guru justifies his earthly greed with spiritual obscurantism. But as this strange group's numbers and wealth grew, so did the corruption, culminating in a deadly clash with locals and a bitter battle against the government.įor the purposes of "Wild Wild Country," Osho is a mere charismatic figurehead, driving around in a fleet of Rolls-Royce cars and wearing Rolex watches. As more and more seekers flocked to him, the organization began building a utopian commune in the rural Oregon countryside. The film interweaves intimate portraits of men and women who have been branded sex offenders with the heartbreaking stories of those who have suffered sexual. "Osho" was a famed Indian spiritualist, meditation teacher, and all-around guru who brought his red-clad followers to the United States in the 1980s. ![]() The Audiogalaxy Satellite client grew in popularity, and the LimeWire client and BitTorrent protocol were released. This drove users to other P2P applications and file sharing continued its growth. Shortly after its loss in court, Napster was shut down to comply with a court order. In October 2001, the MPAA and the RIAA filed a lawsuit against the developers of Kazaa, Morpheus and Grokster that would lead to the US Supreme Court's MGM Studios, Inc. The network was proprietary and encrypted, and the Kazaa team made substantial efforts to keep other clients such as Morpheus off of the FastTrack network. Its FastTrack network was distributed, though, unlike Gnutella, it assigned more traffic to 'supernodes' to increase routing efficiency. In September the eDonkey2000 client and server software was released. In July, Freenet was released and became the first anonymity network. In the Gnutella network, all connecting software was considered equal, and therefore the network had no central point of failure. Gnutella, released in March, was the first decentralized file-sharing network. Gnutella, eDonkey2000, and Freenet were released in 2000, as MP3.com and Napster were facing litigation. In the case of Napster, it has been ruled that an online service provider could not use the "transitory network transmission" safe harbor in the DMCA if they had control of the network with a server. In December 1999, Napster was sued by several recording companies and lost in A&M Records, Inc. ![]() It is generally credited as being the first peer-to-peer file sharing system. In June 1999, Napster was released as an unstructured centralized peer-to-peer system, requiring a central server for indexing and peer discovery. In 1998, MP3.com and Audiogalaxy were established, the Digital Millennium Copyright Act was unanimously passed, and the first mp3 player devices were launched. The mp3 encoding, which was standardized in 1991 and substantially reduced the size of audio files, grew to widespread use in the late 1990s. Internet Relay Chat (1988) and Hotline (1997) enabled users to communicate remotely through chat and to exchange files. Computers were able to access remote files using filesystem mounting, bulletin board systems (1978), Usenet (1979), and FTP servers (1970's). Comparison of Internet Relay Chat clientsįor a chronological guide, see Timeline of file sharing.įiles were first exchanged on removable media.There are absolutely no limitations expect that the maximum size of individual files should not exceed 2 GB.Practice of distributing or providing access to digitally stored information Other than sync, FolderShare can also be used to download files in shared folders from any computer remotely via the web browser. Similarly if you transfer new pictures from the digital camera to the home computer, they’ll be instantly available on your office computers and laptop provided they are connected to the web. You then select files / folders that are to be shared – it could your MyDocuments folder, iTunes Music, Browser Bookmarks, PDF collection or anything else.įolderShare runs in the background (as a taskbar icon) and synchronizes files over the Internet.Īs an example, if you download a Word document from the Office computer to your Home computer for editing, FolderShare will automatically replace the old copy on the Office computer with the new edited version. Here’s how FolderShare works – you install this small program on each of the computers that need to share or access data from other computers. But is it a practical approach when you have dozens of folders containing hundreds of files.Īssuming that all you computers (that need to share data) are connected to the internet, a neat and painless solution is FolderShare, a free software utility from Microsoft that works on Windows as well as Mac. One of the options is to carry your data (photos, music, documents, videos, etc) on an external hard-drive, USB stick or burn it to a CD / DVD. That’s not all, you also carry a laptop when travelling and wish you had access to both entertainment stuff and work related data that’s currently scattered across different computers. The problem gets worse if you maintain a mix of Windows and Mac machines.įor instance, you could have photos and songs on the home computer, documents & presentations are stored on the Office computer but you often need to access them from the home computer especially on days when you are working from home. Anyone who works on multiple computers knows how tough it can get to manually share or synchronize files and folders between different computers. If you use a special 'syntax' or syntaxes for the locator part it will in all likelihood not be too hard to parse that too if you provide a description and/or some examples. If you show me I'll do my best to cover it. ![]() It is not clear to me how year or author are suppressed in the MMD format. It would be used from the command line like this: # TODO: handle indented code blocks (non-trivial), Use open qw(:std :utf8) # undeclared streams in UTF-8 #$%&-+?~/_ letters and numbers, and start with a letter, number or _ conversion to Pandoc's format is trivial.Ī perl script which covers the basic format from the MMD manual page I linked to is very simple: If your citekeys (the KEY part in `` don't contain any characters other than. The two variants `` and ``Īre not a problem it is easy to write a regular expression which covers both and passes the data to a reformatting routine. I'm sure it would not be too hard to write a preprocessor in Perl or Python which converts MMD-style citations into Pandoc-style ones. If you can describe in what way do your MMD citation links differ from the ones shown at ![]() ![]() > the published year, the authors aso which makes it complicated. The two formats have the options of showing/not showing > the way I have used it so far, but I can see that some editors have more Unfortunately this is not done easily with search and replace. ![]() ![]() Switch Audio File Converter is another audio converter (free download) worth exploring. Output: AAC, AC3, AMR, APE, CAF, CDA, FLAC, M3U, M4A, M4B, M4R, MP1, MP2, MP3, MPC, OGG, OPUS, RAW, RSS, WAV, WMA, and more Input: AAC, AC3, AMR, APE, ASF, AVI, CAF, CDA, FLAC, M2A, M3U, M4U, M4B, M4R, MKA, MKV, MP1, MP2, MP3, MP4, MPA, OGA, OGG, OPUS, WMA, WMV, and more The Pazera app comes with support for 23 languages, making it one of the more accessible free audio file converter products online. However, Pazera’s advanced settings are more suited for experienced audiophiles. Pazera’s interface is easy for new users to pick up, and includes predefined settings to make things even easier for beginners. You can also use this software to extract audio clips from video without losing audio quality, split files into pieces (like chapters of an audiobook), and customize encoding parameters like sampling frequency, audio bitrate, and more. Pazera Free Audio Extractor can be used to convert over 70 audio and video formats. Output: MP3, AAC, AC3, E-AC3, Ogg-Opus, Ogg-Vorbis, WMA, FLAC, M4A-AAC, M4A-ALAC, WV (WavPack), MKA-Opus, CAF-Opus, AIFF, WAVĬNET rating: 4.25 out of 5 stars, 82 good reviews out of 96 Input: AVI, AAC, AC3, APE, AMV, ASF, DIVX, FLV, MPG, MPEG, MPE, MKV, MOV, M2TS, MP4, M4V, MXF, MKA, OGG, VOB, RMVB, SWF, WEBM, WMV, 3GP, 3GPP, 3G2, 3GP2, 3GA, and more ![]() Sometimes there are more than 60 ways to. The object is two-fold: to place all the puzzle pieces with police cars on the game board AND to place them in such a way that all escape routes for the red car are blocked off. People Who Viewed This Item Also Viewed 50 Pcs Mini Road Cones Toy Road Sign Miniature Toys Educational Toys Toy Car C $17. In RoadBlock, you start a challenge by placing the buildings and the red car according to the positions shown in the booklet. ![]() ![]() Color: Orange, white -Material: Plastic -Size: About 3.60X2.50cm/1.41X0.98in Package includes 50 x Traffic Cones Model Toys Contact US 1.If you have some inquires or problems, Please feel free to contact us.2.We will reply your email within 1 business day (except weekend).3.When delivery is delayed or items are damaged during delivery, please email us first before you leave feedback. Widely uses: Suitable for classroom teaching of toddlers and kids, as sand table toys, or decorate traffic-themed parties. Sufficient quantity: These miniature traffic cones have enough quantity to meet different needs, and your kids can share them with friends. Roadblock by SmartGames for iOS By SmartGames LIVE Free Developers Description By SmartGames LIVE One of the best-selling games in its range is now available as an App too 130 challenges to. Fun gifts: These traffic sign models can be given to kids, entertain and promote creative connections with other things. allows us to alleviate fear of failure, a common roadblock to creativity. Exquisite workmanship: The traffic cone toys have bright colors and a scaled-down shape, looking very delicate. The creativity involved in constructing playthings and games by using items. Features -Early education props: The traffic cone models can be used as teaching props for traffic knowledge. Given them to kids, entertain and promote creative connections with other things. Please check our similar games Schools out Its time to play and get X2 in Achievements & XP. 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Environmentally friendly material containing no asbestos or volatile compounds. Systems, FIND Henry AT YOUR LOCAL HOMEIMPROVEMENT STORE. Metal ions are essential for all living organisms. Finally, for metal-based antifungal compounds, we refer to the recent review by Lin et al. A significant body of research has been published on the use of nanoparticles as antimicrobial agents and has been reviewed elsewhere 19, 20. The use of metal complexes as adjuvants or potentiators, in combination with antibiotics or other biologically active compounds, is another fertile field of research, but beyond the scope of this Review. A comprehensive look at the molecular and cellular targets of metal ions was published by Lemire et al. 17 recently reviewed bioinorganic strategies against bacteria. This Review does not include a comprehensive list of all metalloantibiotics: interested readers are referred to excellent reviews that have been published on this topic 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16. We conclude by discussing the use of complexes of radioactive metal isotopes to improve the diagnosis of bacterial infections by visualizing their location, in a similar fashion to the detection of cancer through imaging. ![]() The Review includes a brief overview of the application of light-activated metal compounds against bacteria as an example of alternative mechanism of action that are possible with metalloantibiotics. We focus on antibacterial metal complexes and present examples for which the mechanism of action has been (at least partially) elucidated. We discuss the role of metal ions in bacteria and the potential of some metal ions to directly kill bacterial pathogens, along with strategies to hijack bacterial metal-ion pathways for antimicrobial activity. This Review covers the current state of metals and metalloantibiotics as antibacterial agents. However, only recently have metals and metalloantibiotics gained considerable attention as potential antimicrobials, in response to the rapid rise of AMR in the past decade. Since then, many metal-containing compounds have been studied for the treatment of diseases, with several entering human clinical trials 5. ![]() The discovery and regulatory approval of the anticancer drug cisplatin heralded the modern era of medicinal inorganic chemistry. Inorganic compounds, organometallic compounds, and/or metal complexes have had a small but seminal role in twentieth-century medicine. Hence, new approaches for developing the next generation of antibiotics are urgently needed. ![]() Despite this urgency, conventional organic medicinal chemistry has failed to replenish the depleted antimicrobial pipeline: a 2022 analysis showed that, as of June 2021, there were only 45 ‘traditional’ antibiotics in clinical development 4. This number is expected to reach 10 million deaths per year worldwide by 2050 2, if not sooner due in part to the widespread over-prescription of antibiotics to COVID-19 patients over the past 2 years 3. In 2019, there were an estimated 4.95 million deaths associated with AMR, of which 1.3 million were directly attributable to resistant infections 1. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections.Īntimicrobial resistance (AMR) is on track to become the leading cause of death of world in the coming decades. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Green said he once helped documentary makers produce a program on surgical technology in ancient Egyptian, setting up a blind test on the cutting power of obsidian. Obsidian, meanwhile, cleaves into a fine and continuous edge when properly cut. He explained that steel scalpels at a microscopic level have a rough cutting edge that tears into tissue, a function of the crystals that make up the metal. ![]() ![]() “It makes for the best cosmetic outcome.” “The biggest advantage with obsidian is that it is the sharpest edge there is, it causes very little trauma to tissue, it heals faster, and more importantly, it heals with less scarring,” he said. Were mystery holes in skulls an ancient aspirin? Scholars can't explain the purpose behind the mysterious, multiple openings. Healed bone around the edge of the holes indicates the patient was alive during the surgery and likely survived. Lee Green, professor and chairman of the Department of Family Medicine at the University of Alberta, says he routinely uses obsidian blades.Īn ancient surgeon in Peru likely used a sharp tool to carefully groove the perfect circles in this Incan skull. When you consider that most household razor blades are 300 to 600 angstroms, obsidian can still cut it with the sharpest materials nanotechnology can produce.Įven today, a small number of surgeons are using an ancient technology to carry out fine incisions that they say heal with minimal scarring.ĭr. Obsidian – a type of volcanic glass – can produce cutting edges many times finer than even the best steel scalpels.Īt 30 angstroms – a unit of measurement equal to one hundred millionth of a centimeter – an obsidian scalpel can rival diamond in the fineness of its edge. It could even have been a form of emergency surgery for battle wounds.īut while there is still conjecture about the real reasons behind the mysterious procedure, what is known is that the implement often used to carry out the primitive surgery was made from one of the sharpest substances found in nature: obsidian. In Neolithic times, trepanation – or drilling a hole into the skull – was thought to be a cure for everything from epilepsy to migraines. ![]() Ever had a headache so big, you felt like drilling a hole in your head to let the pain out? |
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